Simulate eQTL reference panel — simEQTL • MOSTWAS

The function creates a eQTL reference panel for MOSTWAS methods with genotypes, expression, mediator intensities, and QTLs.

simEQTL(
  geno.loc,
  geno.dis,
  nqtl,
  b_qtls.loc,
  b_qtls.dis,
  eqtl_h2.loc,
  eqtl_h2.dis,
  numMed
)

Arguments

geno.loc	data.frame, reference genotypes for local SNPs
geno.dis	data.frame, reference genotypes for distal SNPs
nqtl	integer, sample size
b_qtls.loc	vector, local eQTLs effect sizes
b_qtls.dis	vector, distal eQTLs effect sizes
eqtl_h2.loc	numeric, local heritability of expression
eqtl_h2.dis	numeric, distal heritability of expression
numMed	integer, number of mediators

list of matrices of local and distal simulated genotypes, expression, mediator intensities, vector of final distal eQTL effect sizes